Agrobiodiverstiy and neglected and underutilized species have the potential to magnify nutrition-sensitive agriculture and related livelihood outcomes. In this report, Investing in Rural People and Biodiversity International provides an operational framework to help Investing in Rural People project development teams integrate neglected and underutilized species into their activities. Although the guidance is targeted at Investing in Rural People activities, the framework can be more widely used by agriculture and nutrition-sensitive programmers and implementers.