This communication introduces the Manual for Developing and Implementing Monitoring Systems for Home Fortification Interventions, a comprehensive tool that includes monitoring concepts and frameworks and provides monitoring instruments as well as worksheets. The manual describes the steps of developing and implementing a monitoring system for home fortification interventions, including identifying and engaging stakeholders; developing a program description, including a logic model and logical framework; refining the purpose of the monitoring system; identifying users and their monitoring needs; describing the design of the monitoring system; developing indicators; describing the core components of a comprehensive monitoring plan; and considering factors related to stage of program development, sustainability, and scale-up.