This report describes the Integrated Anemia Control Strategy (IACS), which was implemented in Nicaragua in 1994. The comprehensive strategy included supplementation for pregnant women and children under 5 years of age, periodic anthelminthic treatment for children, wheat flour fortification with iron and B vitamins, interventions to control vitamin A deficiency (supplementation and fortification of table sugar), behavior change communication, trainings of different actors, strengthening of other public health interventions, and a program monitoring and evaluation (M&E) system.