This handbook describes and presents guidelines for the manufacture and handling of three supplementary food products for vulnerable populations in Zambia, or for production in Zambia and distribution to countries in the region with similar vulnerable populations. The three supplementary food products—ProKal 629, ProKal 10224, and ProKal P2L—were developed as supplementary foods for, respectively, (1) HIV-positive pregnant and lactating women, who are being reached via antenatal care or prevention-of-mother-to-child transmission services; (2) their children 6 to 24 months of age; and (3) other orphans and vulnerable children 6 to 24 months of age. All of the ProKal products are supplementary foods intended to be used by the target beneficiaries in addition to their regular diet to meet their energy and nutrient needs.