This sampling guide was developed to help program implementers conduct participant-based surveys to collect data for select Feed the Future annual monitoring indicators. This updated and revised version reflects the new U.S. Agency for International Development Global Food Security Strategy by integrating the Feed the Future phase two annual monitoring indicators. The guide provides a technical roadmap for those wanting to design, plan, and implement participant-based surveys and focuses on select Feed the Future agriculture-related indicators that are considered more challenging in terms of data collection. Indicators relating to other sectors, such as maternal and child health and nutrition, and water, sanitation, and hygiene, are also discussed. While the original guide focused on indicators of totals only, the updated and revised guide also covers indicators of proportions and means.