Maternal depression can have a great impact on the health and development of both a mother and her child during pregnancy and for up to a year postpartum. This brief explores the risk factors that can lead to maternal depression, focusing heavily on the potential role specific nutrients play in supporting a mother’s mental health and the fetus’ development. It also discusses nutrition interventions during pregnancy, acknowledging where there is room for improvement, especially regarding preventative measures in low- and middle-income countries.