Researchers evaluated 32 responsive caregiving and early learning projects in 17 low- and middle-income countries on 4 continents to identify human resources and curricula critical for program implementation. Human resources themes that emerged range from worker characteristics and incentives to training and supervision. Curricula themes that emerged include flexible adaptation of content and delivery, fidelity, and intervention duration. The authors suggest that stakeholders pay special attention to these themes when designing and implementing programs.