An analysis of longitudinal information on preschool-age children and their households in Ghana informs this study. Authors focus on the relationship between three levels of food-insecure households and early childhood development domains across three years. They conclude that children from households with transitory food insecurity—food insecurity that only occurs in one wave—experienced decreased numeracy, short-term memory, self-regulation, and literacy. Literacy skills continued to decrease for children from persistently food-insecure households or households that experience food insecurity in two or all waves. The authors believe that these findings can help stakeholders develop multi-sectoral early-childhood strategies.