As USAID has increased its commitments to invest in wasting, it has raised the importance of reducing wasting through both prevention and treatment. There is potential to help reduce wasting through the food system as several key drivers of wasting are rooted in food systems—namely the immediate driver of unhealthy diets and the underlying driver of household food insecurity. In this brief, we synthesize the existing evidence base on reducing wasting through food systems approaches, summarize implementation considerations, and recommend areas for further research based on evidence gaps.