Small and sick newborns face serious risk of developmental delays, but most newborns can survive and thrive, provided they have access to quality nurturing care. This package summarizes nurturing care evidence and best practices for this population. It includes an updated evidence review of the core elements of developmentally supportive, family-centered, and nurturing care; implementation experience from seven countries with high-, middle- and low-income settings; and a gap analysis to inform future research.