The USAID framework for Collaborating, Learning, and Adapting supports partners to adapt during unanticipated challenges using real-time evidence. This blog post describes how USAID Advancing Nutrition used the CLA framework to create an internal COVID-19 task force and working groups that monitored and disseminated emerging information, synthesized best practices for virtual engagement, developed guidance for remote data collection, and helped project teams develop new skillsets to support quick pivots in operational and technical work in response to the pandemic.