Reducing undernutrition requires a commitment from multiple sectors, yet documentation on how to collaborate across sectors to reach global goals is scant. Through a three-country assessment and literature review, the Strengthening Partnerships, Results, and Innovations in Nutrition Globally (SPRING) project investigated approaches to multi-sectoral collaboration for nutrition. This paper highlights lessons that USAID and its implementing partners learned, and provides a series of recommendations to guide the designing, implementing, and monitoring of future collaboration.