This review describes current guidelines and recommendations, as stated by WHO, on iron folic acid (IFA) supplementation and multiple micronutrient supplementation (MMS) among adolescents and young children in low- and middle-income countries. It also outlines evidence that suggest that MMS may potentially be more beneficial than IFA supplementation alone. Finally, it calls for more research such as School-based Assessments of Micronutrient Interventions in Adolescents (SAMIA) that seeks to clarify the optimal formulation for supplementation.